Enabling the bioeconomy revolution with
the fastest enzymes
Enzyme is the core hardware of biomanufacturing
The green transition of the world economy needs efficient biosolutions.
In labs around the world, there are now numerous proof-of-concept biosolutions, going from 0 to 1, offering endless promises for a sustainable economy.
Looking at the market, there are still too few biosolutions being economically competitive against fossil fuel-based ways, the “1 to 100”.
A bioeconomy revolution needs an enzyme engineering revolution
In essence, synthetic biopathways are linked enzymatic steps catalyzing conversions one step after another, eventually from feedstocks to products.
It’s impossible to have a fast bioprocess when the enzymes are slow. It’s hard to have a slow bioprocess when the enzymes are fast.
The ENZIDIA® Enzyme Engineering Platform
EvolutionaryDE x UnleashedDrop x MillionFull
Enzyme engineering is fundamentally constrained by two bottlenecks: screening throughput (the numbers game), and data (the information game).
1. The numbers game
2. The information game
The ENZIDIA wheel: an "AI-second" platform
1. Build and screen a massive library (~1010 per run)
2. Collect big data (~106 per run)
3. Learn from the big data through AI
4. Construct the next massive & intelligent library, guided by AI + big data, looping to step 1.
This loop multiplies the “numbers“ advantage (107 x) and “data“ advantage (104 x), poised to revolutionise the way enzymes are engineered.
The ENZIDIA platform has been breaking enzyme bottlenecks on a roll
Two enzymes, from two distinct classes, have been engineered by beta versions of the ENZIDIA platform. Large improvements were obtained in both cases, in just one to two rounds of engineering. Iterations can be easily done for further improvements.
Great surprises await us as the full platform is deployed for more enzymes.
A dataset with ~100,000 data points
(also plotted are ~400k sequences with premature stop codons, which clustered around 0)
The benchmark sequence is commonly used in patents and papers.
Enzyme performance is defined as product formation in a given timeframe.
The data revealed >10k unique sequences with significantly improved performance, and ~100k positive & negative mutations/epistatic interactions.
Should our next project be the super-charged engineering of an enzyme/pathway in your bioprocess?
A new paradigm of enzyme engineering
The Enzidia Team
Let Enzidia accelerate your bottleneck enzyme
We also offer pilot studies without significant commitments from you.
We are also open to establishing exclusive co-development partnerships in a project-specific way.
Additionally, in partnership agreements with ENZIDIA, we place no restriction on the partner to disclose the success or failure of partnership projects. This is not a common practice. While we may not remain successful in 100% of the cases we work on (so far we are), we believe that having such transparency is essential to establish ENZIDIA as the best and most trusted choice in the industry.
Co-development partnership: Enzidia is developing several long-term bioprocess projects internally. We will not take on service requests for these projects, but welcome de-development partners for their scale-up production. The list includes: 1) Pathways for using electrochemicals as feedstock (formate, methanol, acetate), 2) Chitosan production from chitin, 3) 3-HP, 4) Isoprene, 5) PFAS degrading enzymes, 6) Plastic (non-PET)-hydrolysing enzymes.
If you are looking to make your bioprocess the most competitive on the market, get in touch today by booking a meeting or sending a message to our founding team.
FAQ
Most enzymes used in industrial biotech can fit the ENZIDIA platform. The current version of the platform is especially suited for enzymes involved in cell factories.
We will let you know whether a problem can fit our platform, and if so, the difficulty level on a scale of 1-10. Just book a call or write a message with the buttons right below this section.